Subependymal and intraventricular hemorrhages in the newborn

Am J Pathol. 1974 Dec;77(3):465-75.


The pathogenesis of intraventricular hemorrhage in the newborn includes that of subependymal hemorrhage (SEH), the single most common pathologic alteration seen in the brains of 417 consecutively autopsied infants. A clearly recognizable relationship of SEH to gestational age and clinical status exists in that all SEH occur in premature infants under 2500 g birthweight (although only 56% of all premature infants have SEH) and 95% of SEH occur in infants with the respiratory distress syndrome (although only 60% of infants with the respiratory distress syndrome have SEH). The pathogenesis appears to involve a combination of hypoxia, metabolic acidosis, venous stasis and rupture of the thin-walled veins so prominent in the germinal matrix.

MeSH terms

  • Birth Weight
  • Brain / pathology
  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / pathology
  • Cerebral Ventricles
  • Ependyma
  • Erythrocytes
  • Female
  • Hemosiderin / analysis
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / etiology*
  • Phagocytosis
  • Pregnancy
  • Respiratory Distress Syndrome, Newborn / complications
  • Subarachnoid Hemorrhage / etiology
  • Subarachnoid Hemorrhage / pathology


  • Hemosiderin