Canine Gaucher disease--the enzymic defect

Aust J Exp Biol Med Sci. 1979 Oct;57(5):551-4. doi: 10.1038/icb.1979.56.

Abstract

beta-Glucosidase activity was investigated in tissues from a case of canine Gaucher disease and from a normal dog. In the latter, enzyme activity showed two pH optima at pH 4-0-4-25 and pH 5-0-5-5. In Gaucher disease tissues, negligible activity could be measured at the mouse acidic pH.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / enzymology
  • Disease Models, Animal*
  • Dog Diseases / enzymology*
  • Dogs
  • Gaucher Disease / enzymology
  • Gaucher Disease / veterinary*
  • Glucosidases / metabolism*
  • Granulocytes / enzymology
  • Humans
  • Hydrogen-Ion Concentration
  • Liver / enzymology
  • Lymphocytes / enzymology
  • Taurocholic Acid / pharmacology
  • beta-Glucosidase / blood
  • beta-Glucosidase / metabolism*

Substances

  • Taurocholic Acid
  • Glucosidases
  • beta-Glucosidase