Capillary ultrastructure in human metastatic brain tumors

J Neurosurg. 1979 Jul;51(1):53-8. doi: 10.3171/jns.1979.51.1.0053.


The ultrastructural characteristics of blood vessels within 18 metastatic neoplasms of the brain have been studied. The abnormal permeability to protein-bound tracers was found to be related to defective capillary endothelium. Abnormalities include gap functions, fenestrations of membranes, and open normal junctions. The abnormal capillaries had the character of capillaries from current tissue. Endothelium cell abnormalities were not found in surrounding edematous brain.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood-Brain Barrier
  • Brain / blood supply
  • Brain Neoplasms / blood supply*
  • Brain Neoplasms / ultrastructure
  • Capillaries / ultrastructure
  • Capillary Permeability
  • Humans
  • Neoplasm Metastasis