The three-dimensional structure of tubulin protofilaments

Nature. 1979 Jun 14;279(5714):607-12. doi: 10.1038/279607a0.


A three-dimensional image of tubulin protofilaments, reconstructed to 20 A resolution from electron micrographs of negatively stained zinc-induced sheets, has been used to generate an improved model for microtubule substructure. This model has been used to phase a reconstructed image from X-ray amplitudes, which is compatible with the electron microscope results.

MeSH terms

  • Crystallography
  • Glycoproteins*
  • Macromolecular Substances
  • Microscopy, Electron
  • Microtubules / ultrastructure*
  • Protein Binding
  • Tubulin*
  • X-Ray Diffraction
  • Zinc / pharmacology


  • Glycoproteins
  • Macromolecular Substances
  • Tubulin
  • Zinc