Effect of 1(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) on Sato lung carcinoma (SLC). Preliminary result of immunochemotherapy for SLC by combination of ACNU and Propionibacterium acnes

Oncology. 1979;36(1):7-10. doi: 10.1159/000225309.


ACNU was highly effective for Sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of ACNU for SLC showed clear dependence upon tumor size. Nonspecific activation of host-defence mechanism by Propionibacterium acnes contributed to the suppression for the regrowth of solid SLC treated by ACNU.

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / immunology
  • Lung Neoplasms / therapy*
  • Male
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / immunology
  • Neoplasms, Experimental / therapy*
  • Nitrosourea Compounds / therapeutic use*
  • Propionibacterium acnes*
  • Rats


  • Antineoplastic Agents
  • Nitrosourea Compounds