Distinction between the preneoplastic and neoplastic state of murine mammary glands

Proc Natl Acad Sci U S A. 1972 Jun;69(6):1478-80. doi: 10.1073/pnas.69.6.1478.


We have, using nuclear magnetic resonance spectroscopy, measured the relaxation times and diffusion coefficient of water protons in primary mammary adenocarcinomas of mice. In our biological model, three morphological stages were defined: (a) mammary gland tissue from pregnant mice, (b) preneoplastic nodules, and (c) neoplastic tissue. It was found that neoplastic tissues could be distinguished from normal and prenoeplastic tissue. Spin-spin and spin-lattice relaxation times and the diffusion coefficient of water protons are increased in the neoplastic tissue relative to mammary gland tissue from pregnant mice and preneoplastic nodule tissue.

MeSH terms

  • Adenocarcinoma / physiopathology
  • Animals
  • Diffusion
  • Female
  • Magnetic Resonance Spectroscopy
  • Mammary Glands, Animal / physiology*
  • Mammary Glands, Animal / physiopathology
  • Mammary Neoplasms, Experimental / physiopathology*
  • Mice
  • Mice, Inbred Strains
  • Pregnancy
  • Protons
  • Water


  • Protons
  • Water