Antagonistic properties of N-methyl-N'-[2-(5-ethyl-4-imidazolyl-methylthio)ethyl]thiourea

Farmaco Sci. 1979 May;34(5):403-8.


In the present paper the Authors describe the synthesis and the biological effects of N-methyl-N'-[2-(5-ethyl-4-imidazolylmethylthio)ethyl]thiourea (etiamide). This compound appeared to inhibit, to a certain extent, the effect of histamine on H2-receptors. This inhibition, however, was less pronounced than that elicited by metiamide and in some of the preparations examined appeared to be of the non-competitive type.

MeSH terms

  • Animals
  • Cats
  • Female
  • Guinea Pigs
  • Histamine H2 Antagonists / chemical synthesis*
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • In Vitro Techniques
  • Rats


  • Histamine H2 Antagonists
  • Imidazoles
  • etiamide