The 1970 yellow fever epidemic in Okwoga District, Benue Plateau State, Nigeria. 3. Serological responses in persons with and without pre-existing heterologous group B immunity

Bull World Health Organ. 1973;49(3):235-44.


Serological studies of persons infected with yellow fever (YF) during the 1970 epidemic in Okwoga District, Nigeria, indicated that epidemic YF occurred despite a high prevalence of pre-existing group B arbovirus immunity, which increased with age. The viruses involved were primarily dengue, Zika, and Wesselsbron. Patterns of responses of haemagglutination-inhibiting, complement-fixing, and neutralizing antibodies in primary YF and in superinfections are defined in this paper.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Heterophile / analysis*
  • Antibodies, Viral / analysis
  • Arboviruses / immunology*
  • Child
  • Child, Preschool
  • Complement Fixation Tests
  • Disease Outbreaks*
  • Hemagglutination Inhibition Tests
  • Humans
  • Immunity, Active*
  • Infant
  • Neutralization Tests
  • Nigeria
  • Yellow Fever / epidemiology
  • Yellow Fever / immunology*
  • Yellow fever virus / immunology


  • Antibodies, Heterophile
  • Antibodies, Viral