On the pathogenesis of the uremic state. An exposition of the "trade-off hypothesis"

N Engl J Med. 1972 May 18;286(20):1093-9. doi: 10.1056/NEJM197205182862009.
No abstract available

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Biological Transport
  • Diet
  • Dogs
  • Glomerular Filtration Rate
  • Humans
  • Hyperparathyroidism, Secondary / etiology
  • Kidney / pathology
  • Kidney / physiopathology*
  • Kidney Tubules / physiopathology
  • Parathyroid Hormone / physiology
  • Phosphates / blood
  • Phosphates / metabolism
  • Rabbits
  • Rats
  • Sodium / metabolism
  • Uremia / blood
  • Uremia / complications
  • Uremia / etiology
  • Uremia / metabolism
  • Uremia / pathology
  • Uremia / physiopathology*
  • Water-Electrolyte Balance

Substances

  • Parathyroid Hormone
  • Phosphates
  • Sodium