Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity

Gastroenterology. 1978 Jul;75(1):95-9.


Sulfasalazine hepatotoxicity has been poorly documented in the literature. We report a case of a young female with inflammatory bowel disease who developed severe hepatotoxicity as part of a systemic hypersensitivity reaction to sulfasalazine. The clinical, biochemical, and histopathological features resemble those of sulfonamide-induced hepatic injury. Although rare, our case as well as previous reports indicate the serious nature of the illness.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Drug Hypersensitivity / pathology*
  • Female
  • Humans
  • Inflammatory Bowel Diseases / drug therapy
  • Liver / pathology
  • Sulfasalazine / adverse effects*
  • Sulfasalazine / therapeutic use


  • Sulfasalazine