Abstract
The addition of mannitol to cultures of Salmonella typhimurium mutants missing mannitol-1-phosphate dehydrogenase causes stasis or lysis. Mannitol-1-phosphate accumulates intracellularly to concentrations of 20 mm. The incorporation of acetate into lipid is inhibited before cell wall, protein, or nucleic acid synthesis.
MeSH terms
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Acetates / antagonists & inhibitors
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Alcohol Oxidoreductases / metabolism
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Bacterial Proteins / biosynthesis
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Bacteriolysis
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Carbon Isotopes
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Cell Wall / metabolism
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Chromatography, Paper
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Genetics, Microbial
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Lipids / biosynthesis
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Mannitol / metabolism
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Mannitol / pharmacology*
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Microbial Sensitivity Tests
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Mutation
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Nucleic Acids / biosynthesis
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Phenylalanine / metabolism
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Pimelic Acids / metabolism
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Salmonella typhimurium / drug effects*
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Salmonella typhimurium / enzymology
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Salmonella typhimurium / growth & development
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Salmonella typhimurium / metabolism
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Stereoisomerism
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Time Factors
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Tritium
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Uracil / metabolism
Substances
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Acetates
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Bacterial Proteins
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Carbon Isotopes
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Lipids
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Nucleic Acids
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Pimelic Acids
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Tritium
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Mannitol
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Phenylalanine
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Uracil
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Alcohol Oxidoreductases