Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 May 1;137(5):1142-62.
doi: 10.1084/jem.137.5.1142.

Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice. I. Morphology, Quantitation, Tissue Distribution

Free PMC article

Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice. I. Morphology, Quantitation, Tissue Distribution

R M Steinman et al. J Exp Med. .
Free PMC article

Abstract

A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1-1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.

Comment in

Similar articles

See all similar articles

Cited by 558 articles

See all "Cited by" articles

References

    1. J Exp Med. 1966 Jan 1;123(1):145-60 - PubMed
    1. J Exp Med. 1966 Oct 1;124(4):557-71 - PubMed
    1. J Histochem Cytochem. 1966 Apr;14(4):291-302 - PubMed
    1. Science. 1967 Dec 22;158(3808):1573-5 - PubMed
    1. J Exp Med. 1968 Feb 1;127(2):277-90 - PubMed
Feedback