Mode of action of lividomycin on protein synthesis in Escherichia coli

Antimicrob Agents Chemother. 1973 Sep;4(3):380-2. doi: 10.1128/AAC.4.3.380.

Abstract

Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reaction.

MeSH terms

  • Amino Acids / metabolism
  • Bacterial Proteins / biosynthesis*
  • Carbon Radioisotopes
  • Cell-Free System
  • Escherichia coli / metabolism*
  • Genetic Code
  • Paromomycin / pharmacology*
  • Peptide Chain Initiation, Translational / drug effects
  • Phenylalanine / metabolism
  • Poly U / metabolism
  • Protein Binding / drug effects
  • RNA, Transfer / biosynthesis
  • Ribosomes / metabolism
  • Thymidine / metabolism
  • Tritium
  • Uracil / metabolism

Substances

  • Amino Acids
  • Bacterial Proteins
  • Carbon Radioisotopes
  • Tritium
  • Poly U
  • Phenylalanine
  • Uracil
  • Paromomycin
  • RNA, Transfer
  • Thymidine