Abstract
Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reaction.
MeSH terms
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Amino Acids / metabolism
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Bacterial Proteins / biosynthesis*
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Carbon Radioisotopes
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Cell-Free System
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Escherichia coli / metabolism*
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Genetic Code
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Paromomycin / pharmacology*
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Peptide Chain Initiation, Translational / drug effects
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Phenylalanine / metabolism
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Poly U / metabolism
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Protein Binding / drug effects
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RNA, Transfer / biosynthesis
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Ribosomes / metabolism
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Thymidine / metabolism
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Tritium
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Uracil / metabolism
Substances
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Amino Acids
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Bacterial Proteins
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Carbon Radioisotopes
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Tritium
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Poly U
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Phenylalanine
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Uracil
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Paromomycin
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RNA, Transfer
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Thymidine