Recurrent granular corneal dystrophy

Am J Ophthalmol. 1975 Jan;79(1):18-24. doi: 10.1016/0002-9394(75)90451-1.


Four full-thickness corneal buttons and tissue from one lamellar keratoplasty, derived from four patients with granular corneal dystrophy recurring in previously transplanted corneas, were studied by light and transmission electron microscopy. Fibrous tissue without vascularization was present between the epithelium and Bowman's membrane and contained deposits characteristic of granular dystrophy in both light and electron microscopy. The recurrence of dystrophy in the normal donor cornea is the result of infiltration of the grafted cornea by host invasion. The donor stroma is spared.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Cornea / pathology*
  • Cornea / ultrastructure
  • Corneal Dystrophies, Hereditary / pathology*
  • Corneal Transplantation
  • Descemet Membrane / ultrastructure
  • Epithelium / ultrastructure
  • Female
  • Fibroblasts / ultrastructure
  • Humans
  • Male
  • Membranes / ultrastructure
  • Microscopy, Electron
  • Microscopy, Polarization
  • Middle Aged
  • Recurrence
  • Staining and Labeling
  • Transplantation, Homologous
  • Visual Acuity