A comparative study of the effect of normal substrates and 5-iodo-2'-deoxyuridine triphosphate, a metabolic analog of thymidine triphosphate, on the inactivation of Escherichia coli deoxyribonucleic acid polymerase I and II by ultraviolet irradiation

J Biol Chem. 1974 Feb 25;249(4):1239-46.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cattle
  • Chlorides / pharmacology
  • DNA
  • DNA Nucleotidyltransferases / antagonists & inhibitors
  • DNA Nucleotidyltransferases / metabolism*
  • DNA Nucleotidyltransferases / radiation effects
  • Deoxyribonucleotides / pharmacology
  • Deoxyuracil Nucleotides
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Escherichia coli / enzymology*
  • Free Radicals
  • Hydrogen-Ion Concentration
  • Idoxuridine / pharmacology
  • Kinetics
  • Magnesium / pharmacology
  • Radiation Effects
  • Structure-Activity Relationship
  • Templates, Genetic
  • Thymine Nucleotides / metabolism*
  • Thymus Gland
  • Tritium
  • Ultraviolet Rays*
  • Uracil Nucleotides / administration & dosage
  • Uracil Nucleotides / pharmacology*

Substances

  • Chlorides
  • Deoxyribonucleotides
  • Deoxyuracil Nucleotides
  • Free Radicals
  • Thymine Nucleotides
  • Uracil Nucleotides
  • Tritium
  • 5-iodo-2'-deoxyuridine triphosphate
  • DNA
  • DNA Nucleotidyltransferases
  • Magnesium
  • Idoxuridine