Metabolism and pharmacokinetics of a new nonsteroid, anti-inflammatory agent, 2-(3-chloro-o-toluidino) nicotinic acid (clonixin) in rats, dogs and monkeys

MeSH terms

• Animals
• Anti-Inflammatory Agents / administration & dosage
• Anti-Inflammatory Agents / blood
• Anti-Inflammatory Agents / metabolism*
• Chromatography
• Dogs
• Dose-Response Relationship, Drug
• Feces / analysis
• Female
• Glucuronates / isolation & purification
• Haplorhini
• Macaca
• Male
• Models, Theoretical
• Nicotinic Acids / administration & dosage
• Nicotinic Acids / blood
• Nicotinic Acids / metabolism*
• Rats
• Spectrophotometry, Ultraviolet
• Sulfates / isolation & purification
• Toluidines / administration & dosage
• Toluidines / blood
• Toluidines / metabolism*
• Tritium