Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation

Arch Biochem Biophys. 1972 Nov;153(1):298-303. doi: 10.1016/0003-9861(72)90448-1.
No abstract available

MeSH terms

  • Animals
  • Benzopyrenes
  • Computers
  • Cytochrome P-450 Enzyme System
  • Cytochromes*
  • Enzyme Activation
  • Kinetics
  • Male
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology*
  • Mixed Function Oxygenases* / antagonists & inhibitors
  • Phenobarbital / pharmacology
  • Rats

Substances

  • Benzopyrenes
  • Cytochromes
  • Methylcholanthrene
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Phenobarbital