Blood eosinophils and eosinophil cationic protein after acute myocardial infarction or corticosteroid administration

Br J Haematol. 1979 May;42(1):147-54. doi: 10.1111/j.1365-2141.1979.tb03707.x.


Measurements of eosinophil cationic protein in serum (S-ECP) have been made in patients with acute myocardial infarction. In spite of low numbers of blood eosinophils in the acute phase of the disease S-ECP levels fluctuated widely with often markedly raised levels. Peak levels of S-ECP were significantly correlated (P less than 0.001) to peak numbers of blood eosinophils, although the former usually occurred within the first 2-3 d of illness and the latter usually after the sixth day. Intravenous injection of 0.5 g methylprednisolone in healthy individuals reduced blood eosinophil counts for at least 24 h, but S-ECP levels remained within normal limits. These results suggest that ECP is released from eosinophils in vivo. The raised levels of S-ECP in patients with acute myocardial infarction are probably due to the active participation of eosinophils in the inflammatory process.

MeSH terms

  • Acute Disease
  • Blood Proteins / analysis*
  • Eosinophils*
  • Granulocytes
  • Humans
  • Inflammation / blood*
  • Inflammation / chemically induced
  • Injections, Intravenous
  • Leukocyte Count
  • Methylprednisolone / administration & dosage
  • Myocardial Infarction / blood*
  • Radioimmunoassay
  • Time Factors


  • Blood Proteins
  • Methylprednisolone