A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens

Br J Pharmacol. 1972 Dec;46(4):764-6. doi: 10.1111/j.1476-5381.1972.tb06901.x.

Abstract

The isolated mouse vas deferens possesses an adrenergic excitatory motor innervation which can be inhibited by low concentrations of morphine (ID50=0.5 muM). This effect of morphine is mediated by specific receptors which are blocked by naloxone. Activation of the morphine receptors inhibits noradrenaline release. It is concluded that adrenergic neurotransmission in the mouse vas deferens differs in some important way from that at the more common, morphine-insensitive, adrenergic junctions.

MeSH terms

  • Animals
  • Electric Stimulation
  • In Vitro Techniques
  • Male
  • Mice
  • Morphine / administration & dosage
  • Morphine / pharmacology*
  • Motor Neurons / drug effects
  • Naloxone / pharmacology
  • Neuroeffector Junction / drug effects*
  • Norepinephrine / analysis
  • Norepinephrine / antagonists & inhibitors
  • Phentolamine / pharmacology
  • Receptors, Adrenergic / drug effects*
  • Vas Deferens / drug effects*

Substances

  • Receptors, Adrenergic
  • Naloxone
  • Morphine
  • Norepinephrine
  • Phentolamine