The flow study and static images of the brain scans of two patients with plasmacytoma of the skull were identical to the pattern most commonly seen with meningioma. There was a prominent blush on dynamic imaging which did not wash out combined with an intense uptake on static views adjacent to a meningeal surface. In patients with known multiple myeloma, the diagnosis of plasmacytoma of the skull or cranial cavity should be considered when this characteristic pattern is seen.