Olivanic acids, a family of beta-lactam antibiotics with beta-lactamase inhibitory properties produced by Streptomyces species. I. Detection, properties and fermentation studies

J Antibiot (Tokyo). 1979 Apr;32(4):287-94. doi: 10.7164/antibiotics.32.287.


The screening of soil actinomyces for beta-lactamase inhibitors is described. Using a plate test a number of strains of Streptomyces were found to produce beta-lactamase inhibitory activity designated olivanic acid complex. Factors affecting the production of this complex by Streptomyces olivaceus ATCC 21379 are reported. The complex showed antibacterial activity and also inhibited a number of different types of beta-lactamase in a progressive manner. Certain ampicillin-resistant bacteria are rendered sensitive to ampicillin in the presence of olivanic acid complex at a concentration which alone did not inhibit growth.

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / pharmacology
  • Fermentation
  • Streptomyces / metabolism*
  • Time Factors
  • beta-Lactamase Inhibitors
  • beta-Lactams / analysis
  • beta-Lactams / biosynthesis
  • beta-Lactams / pharmacology


  • Anti-Bacterial Agents
  • beta-Lactamase Inhibitors
  • beta-Lactams