Faecal bile-acids and clostridia in patients with cancer of the large bowel

Lancet. 1975 Mar 8;1(7906):535-9. doi: 10.1016/s0140-6736(75)91556-1.

Abstract

Of 44 patients with cancer of the large bowel, 36 ( 82%) had high faecal bile-acid concentrations compared with only 15 (17%) out of 90 patients with other diseases. 31 (70%) of the 44 patients with large-bowel cancer had high faecal bile-acid concentrations in the presence of faecal clostridia able to dehydrogenate the bile-acid nucleus, compared with only 8 (9%) out of 90 patients with other diseases. Thes findings support the hypothesis that cancer of the large bowel is caused by high concentrations of bile-acid derivatives produced by certain anaerobic bacteria.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Bile Acids and Salts / analysis*
  • Bile Acids and Salts / metabolism
  • Body Constitution
  • Carcinogens*
  • Clostridium / isolation & purification
  • Clostridium / metabolism*
  • Colonic Neoplasms / etiology*
  • Colonic Neoplasms / microbiology
  • Family Characteristics
  • Feces / analysis*
  • Feces / microbiology
  • Female
  • Gastrointestinal Diseases / microbiology
  • Humans
  • Male
  • Middle Aged
  • Rectal Neoplasms / etiology*
  • Rectal Neoplasms / microbiology
  • Smoking
  • Specimen Handling
  • Steroids / analysis
  • Steroids / metabolism

Substances

  • Bile Acids and Salts
  • Carcinogens
  • Steroids