Vitamins and oral contraceptive use

Lancet. 1975 Mar 8;1(7906):561-4. doi: 10.1016/s0140-6736(75)91570-6.

Abstract

Reports concerning the interaction between steroidal contraceptives (the combined pill) and vitamins indicate that in users the mean serum-vitamin-A level is raised and the mean serum-vitamin-B2 (riboflavine), vitamin-B6 (pyridoxine), vitamine-C, folic-acid, and vitamin-B12 levels are reduced. Other vitamins have been insufficiently studied for comment. Biochemical evidence of co-enzyme deficiency has been reported for vitamin B2, vitamin B6, and folic acid. Clinical effects due to vitamin deficiency have been described for vitamin B6--namely, depression and impaired glucose tolerance. Folic-acid deficiency with megaloblastic anaemia has been reported in only 21 cases.

MeSH terms

  • Anemia, Megaloblastic / chemically induced
  • Ascorbic Acid / blood
  • Avitaminosis / chemically induced*
  • Coenzymes / blood
  • Contraceptives, Oral / adverse effects*
  • Contraceptives, Oral / pharmacology
  • Depression / chemically induced
  • Female
  • Folic Acid Deficiency / chemically induced
  • Glucose Tolerance Test
  • Humans
  • Pyridoxine / blood
  • Riboflavin / blood
  • Vitamin A / blood
  • Vitamin B 12 / blood
  • Vitamin B 6 Deficiency / chemically induced
  • Vitamin B 6 Deficiency / complications

Substances

  • Coenzymes
  • Contraceptives, Oral
  • Vitamin A
  • Pyridoxine
  • Vitamin B 12
  • Ascorbic Acid
  • Riboflavin