Hydrophobic interactions between the 5-alkyl group of 2,4-diamino-6-methylpyrimidines and dihydrofolate reductase

Biochemistry. 1973 Feb 27;12(5):1003-5. doi: 10.1021/bi00729a033.
No abstract available

MeSH terms

  • Alkanes
  • Amines
  • Animals
  • Binding Sites
  • Buffers
  • Folic Acid Antagonists*
  • Kinetics
  • Molecular Conformation
  • Pyrimidines*
  • Sarcoma 180 / enzymology*
  • Spectrophotometry, Ultraviolet
  • Structure-Activity Relationship
  • Thermodynamics
  • Water

Substances

  • Alkanes
  • Amines
  • Buffers
  • Folic Acid Antagonists
  • Pyrimidines
  • Water