Oxime derivatives of erythromycin: inhibitors of Rous sarcoma virus reverse transcriptase activity and focus formation

J Gen Virol. 1975 Jan;26(1):135-9. doi: 10.1099/0022-1317-26-1-135.

Abstract

9-O-methyloximd erythromycin A and its analogue inhibited reverse transcriptase and blocked focus formation of Rous sarcoma virus. These chemicals inhibited neither DNA-dependent DNA polymerase nor DNA-dependent RNA polymerase from bacterial sources. However, they inhibited reverse transcriptase with an apparently differnt mechanism than that by rifamycin ABDP.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Avian Sarcoma Viruses / drug effects*
  • Avian Sarcoma Viruses / enzymology
  • Avian Sarcoma Viruses / growth & development
  • Cell Transformation, Neoplastic / drug effects*
  • Chick Embryo
  • Erythromycin / analogs & derivatives
  • Erythromycin / pharmacology
  • Fibroblasts
  • Reverse Transcriptase Inhibitors*
  • Rifamycins / pharmacology
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Reverse Transcriptase Inhibitors
  • Rifamycins
  • Erythromycin