The effect of GAGPS (Arteparon) was investigated on patients with osteoarthritis of hip-joints in dependence from the method of application. By that way 50 patients got each 6 injections with 125 mg/0,5 ml Arteparon intraarticular and 50 patients each 10 injections with 125 mg/0,5 ml Arteparon intramuscular. We have documented the qualities of pain, function and motility of the treated hip-joints. The tests applied have demonstrated that there is no significant difference between the both applications, in both groups the effect was good to the same extent. The therapeutic effect and the further indications by intramuscular administration of the GAGPS are discussed.