Synthesis and biological evaluation of poly-gamma-glutamyl derivatives of methotrexate

Biochemistry. 1973 Sep 25;12(20):3923-7. doi: 10.1021/bi00744a021.
No abstract available

MeSH terms

  • Animals
  • Biological Assay
  • Carbon Radioisotopes
  • Chromatography, DEAE-Cellulose
  • Chromatography, Ion Exchange
  • Drug Stability
  • Fluorides
  • Glutamates
  • Hydrolases
  • Kidney / enzymology
  • Methotrexate / chemical synthesis*
  • Methotrexate / pharmacology
  • Peptides / chemical synthesis*
  • Peptides / pharmacology
  • Spectrophotometry, Ultraviolet
  • Streptococcus / drug effects
  • Structure-Activity Relationship
  • Swine

Substances

  • Carbon Radioisotopes
  • Glutamates
  • Peptides
  • Hydrolases
  • Fluorides
  • Methotrexate