The 'singles' method for segregation analysis under incomplete ascertainment

Ann Hum Genet. 1979 May;42(4):507-12. doi: 10.1111/j.1469-1809.1979.tb00683.x.


Li & Mantel (1968) proposed a simple new method of segregation analysis under complete ascertainment. This paper shows that, with a slight modification, the method is also valid under incomplete ascertainment. The assumptions concerning ascertainment are discussed and the method compared with the maximum likelihood method and Weinberg's proband method.

Publication types

  • Comparative Study

MeSH terms

  • Genetic Diseases, Inborn / genetics*
  • Humans
  • Models, Biological*
  • Phenylketonurias / genetics
  • Sibling Relations
  • Statistics as Topic