Cholestasis as an in vivo model for analysis of the induction of liver microsomal monooxygenases by sodium phenobarbital and 3-methylcholanthrene

Biochem Pharmacol. 1979 May 1;28(9):1473-8. doi: 10.1016/0006-2952(79)90460-x.
No abstract available

MeSH terms

  • Animals
  • Cholestasis / enzymology*
  • Deoxycholic Acid / pharmacology
  • Enzyme Induction / drug effects
  • In Vitro Techniques
  • Kinetics
  • Lipid Metabolism
  • Male
  • Methylcholanthrene / pharmacology*
  • Microsomes, Liver / enzymology*
  • Mixed Function Oxygenases / biosynthesis*
  • Models, Biological
  • Oxidoreductases / biosynthesis*
  • Oxygen Consumption / drug effects
  • Peroxides / metabolism
  • Phenobarbital / pharmacology*
  • Rats

Substances

  • Peroxides
  • Deoxycholic Acid
  • Methylcholanthrene
  • Mixed Function Oxygenases
  • Oxidoreductases
  • Phenobarbital