A fatal case of inappropriate ADH secretion induced by cyclophosphamide therapy

Cancer. 1979 Sep;44(3):896-8. doi: 10.1002/1097-0142(197909)44:3<896::aid-cncr2820440316>3.0.co;2-9.

Abstract

Cyclophosphamide is used extensively to treat malignancies. A 5-year-old boy with stage IV neuroblastoma is described who developed a fatal syndrome of inappropriate antidiuretic hormone (ADH) secretion after high dose cyclophosphamide therapy.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Gland Neoplasms / drug therapy
  • Child, Preschool
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects*
  • Humans
  • Inappropriate ADH Syndrome / chemically induced*
  • Inappropriate ADH Syndrome / pathology
  • Male
  • Neuroblastoma / drug therapy
  • Pituitary Gland, Posterior / pathology
  • Sodium Chloride / administration & dosage
  • Time Factors

Substances

  • Sodium Chloride
  • Cyclophosphamide