Trans-membrane translocation of proteins. The direct transfer model

Eur J Biochem. 1979 Jun;97(1):175-81. doi: 10.1111/j.1432-1033.1979.tb13100.x.


As a start towards a deeper understanding of the transmembrane transport of proteins, the transfer of a nascent chain through the lipophilic core of a membrane is discussed from a physico-chemical point of view. Some simple considerations of the energetics of protein structure, together with experimental data on the transfer process, form the basis for a detailed and quantifiable model, accounting for the extrusion of secreted proteins as well as for the insertion of trans-membrane proteins.

MeSH terms

  • Amino Acid Sequence
  • Biological Transport*
  • Membrane Proteins / metabolism
  • Membranes / metabolism*
  • Models, Biological
  • Proteins / metabolism*
  • Ribosomes / metabolism


  • Membrane Proteins
  • Proteins