Enhancement of carcinoembryonic antigen expression by interferon

Int J Cancer. 1979 Jul 15;24(1):49-52. doi: 10.1002/ijc.2910240109.

Abstract

Human interferon decreased DNA but not RNA synthesis in a human colon carcinoma cell line, WiDr; in addition, there was a two- to three-fold increase in the expression of a tumor-associated antigen, carcinoembryonic antigen. In contrast, interferon had no effect on a normal human diploid cell line, WI-38. Thus, in addition to its anti-cellular effect against tumor cells, interferon can also modulate tumor antigenicity.

MeSH terms

  • Carcinoembryonic Antigen / analysis
  • Carcinoembryonic Antigen / metabolism*
  • Carcinoma / immunology*
  • Carcinoma / metabolism
  • Carcinoma / therapy
  • Cell Division / drug effects
  • Cell Line
  • Colonic Neoplasms / immunology*
  • Colonic Neoplasms / metabolism
  • Colonic Neoplasms / therapy
  • DNA, Neoplasm / biosynthesis
  • Fibroblasts / metabolism
  • Humans
  • Interferons / pharmacology*
  • Interferons / therapeutic use
  • RNA, Neoplasm / biosynthesis

Substances

  • Carcinoembryonic Antigen
  • DNA, Neoplasm
  • RNA, Neoplasm
  • Interferons