Abstract
A new antimetabolite antibiotic, U-42,126, was discovered by use of a specific in vitro screen. U-42,126 was produced by the fermentation of Streptomyces sviceus. Its antimicrobial activity in vitro was limited to fungi. Certain bacteria were inhibited only when cultivated in completely synthetic media. U-42,126 was active in vivo against L1210 leukemia in mice.
MeSH terms
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Antibiotics, Antineoplastic / pharmacology
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Antifungal Agents / metabolism
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Antifungal Agents / pharmacology*
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Antimetabolites / pharmacology*
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Bacteria / drug effects*
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Chromatography, Paper
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Glycine / pharmacology
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Microbial Sensitivity Tests
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Oxazoles / pharmacology*
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Streptomyces / classification
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Streptomyces / metabolism*
Substances
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Antibiotics, Antineoplastic
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Antifungal Agents
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Antimetabolites
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Oxazoles
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Glycine