Differential effects of localized lesions of n. accumbens on morphine- and amphetamine-induced locomotor hyperactivity in the C57BL/6J mouse

J Comp Physiol Psychol. 1979 Aug;93(4):745-51. doi: 10.1037/h0077605.

Abstract

Mice of the C57BL/6J strain became hyperactive to increasing doses of morphine sulfate. This response was similar to locomotor hyperactivity induced by amphetamine. Lesions and chemical blockade of posterior n. accumbens abolished amphetamine-induced hyperactivity and reduced but did not abolish the morphine response. These experiments demonstrate that the response to the two drugs is mediated by overlapping but noncongruent neural systems.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphetamine / pharmacology*
  • Animals
  • Brain Mapping
  • Haloperidol / pharmacology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Morphine / pharmacology*
  • Motor Activity / drug effects*
  • Nucleus Accumbens / drug effects*
  • Receptors, Dopamine / drug effects*
  • Septal Nuclei / drug effects*
  • Stimulation, Chemical

Substances

  • Receptors, Dopamine
  • Morphine
  • Amphetamine
  • Haloperidol