Lung function in children following repair of tracheoesophageal fistula

J Pediatr. 1979 Jul;95(1):24-7. doi: 10.1016/s0022-3476(79)80076-1.


Lung function and bronchial reactivity by methacholine challenge were studied in 24 patients seven to 18 years after repair of type I tracheoesophageal fistula. Only one patient had no abnormalities of the variables tested. Thirteen patients had obstructive airways disease, five had a restrictive defect, and 15 had a positive methacholine challenge. It is postulated that continuing subclinical aspiration of esophageal contents causes lung damage and renders the airways hyperreactive.

MeSH terms

  • Adolescent
  • Child
  • Female
  • Follow-Up Studies
  • Humans
  • Lung / drug effects
  • Lung / physiopathology*
  • Male
  • Methacholine Compounds / pharmacology
  • Tracheoesophageal Fistula / surgery*


  • Methacholine Compounds