Cholera toxin: interaction of subunits with ganglioside GM1

Science. 1974 Feb 15;183(4125):656-7. doi: 10.1126/science.183.4125.656.


Vibrio cholerae exotoxin is an aggregate of two different noninterconvertible subunits (molecular weights about 15,000 and about 25,000). Only the smaller subunit reacts with ganglioside G(M1), a possible biological receptor. The larger subunit, found only in active toxin molecules, can be eluted with 8 molar urea from insoluble complexes of toxin, ganglioside, and cerebroside.

MeSH terms

  • Binding Sites
  • Cerebrosides
  • Chemical Phenomena
  • Chemistry
  • Electrophoresis, Polyacrylamide Gel
  • Gangliosides*
  • Molecular Weight
  • Toxins, Biological*
  • Urea
  • Vibrio cholerae*


  • Cerebrosides
  • Gangliosides
  • Toxins, Biological
  • Urea