Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme

Genetics. 1974 Jan;76(1):93-7.

Abstract

We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C x NZC F(1) hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure.

Publication types

  • Comparative Study

MeSH terms

  • Alcohol Oxidoreductases / biosynthesis*
  • Alleles
  • Animals
  • Chromosome Mapping
  • Crosses, Genetic
  • Electrophoresis, Starch Gel
  • Female
  • Genes*
  • Genes, Dominant
  • Genetic Linkage
  • Hybridization, Genetic
  • Isoenzymes / biosynthesis*
  • Kidney / enzymology
  • Liver / enzymology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred Strains
  • Molecular Weight
  • Organ Specificity
  • Polymorphism, Genetic

Substances

  • Isoenzymes
  • Alcohol Oxidoreductases