Sampling variances of heterozygosity and genetic distance

Genetics. 1974 Feb;76(2):379-90. doi: 10.1093/genetics/76.2.379.


Mathematical formulae for the sampling variances of average heterozygosity and Nei's genetic distance are developed. These sampling variances are decomposed into their two components, i.e. the inter-locus and intra-locus variances. The relationship between the number of loci and the number of individuals per locus to be examined for estimating average heterozygosity and genetic distance is also discussed. The utility of the inter-locus variance of heterozygosity for studying the mechanism of maintenance of genetic variability in populations is indicated.

MeSH terms

  • Alleles
  • Animals
  • Chromosome Mapping
  • Gene Frequency
  • Genetics, Population*
  • Heterozygote*
  • Humans
  • Mathematics