Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate

Biochem J. 1974 Feb;138(2):313-6. doi: 10.1042/bj1380313.

Abstract

alpha-Cyano-4-hydroxycinnamate greatly inhibits the transport of pyruvate but not that of acetate or butyrate in liver mitochondria and erythrocytes. In the latter, lactate uptake is also inhibited. It is concluded that a specific carrier is involved in membrane transport of pyruvate and that the plasma-membrane carrier may also be involved in lactate transport.

Publication types

  • Comparative Study

MeSH terms

  • Acetates / metabolism
  • Animals
  • Biological Transport, Active / drug effects
  • Butyrates / metabolism
  • Carbon Radioisotopes
  • Cell Membrane / metabolism
  • Cinnamates / pharmacology*
  • Coumaric Acids
  • Erythrocytes / cytology
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism*
  • Humans
  • Lactates / metabolism
  • Membranes / metabolism
  • Mitochondria, Liver / drug effects
  • Mitochondria, Liver / metabolism*
  • Nitriles / pharmacology
  • Organ Specificity
  • Pyruvates / blood
  • Pyruvates / metabolism*
  • Rats
  • Species Specificity
  • Tritium

Substances

  • Acetates
  • Butyrates
  • Carbon Radioisotopes
  • Cinnamates
  • Coumaric Acids
  • Lactates
  • Nitriles
  • Pyruvates
  • Tritium
  • alpha-cyano-4-hydroxycinnamate