Haemoglobin F Malaysia: alpha 2, gamma 2 1(NA1) glycine--cysteine; 136 glycine

J Med Genet. 1974 Mar;11(1):25-30. doi: 10.1136/jmg.11.1.25.

Abstract

Structural studies of an abnormal haemoglobin found in a Chinese newborn but not in her parents, showed it to be a new γ-chain variant, Hb F Malaysia.

The first residue of the γ-chain was Cys and not Gly, and the γ-chain was of the type in which residue 136 is Gly and not Ala.

MeSH terms

  • Asian People
  • Blood Protein Electrophoresis
  • Chromatography, DEAE-Cellulose
  • Cysteine / analysis*
  • Female
  • Fetal Hemoglobin / analysis*
  • Genetic Variation
  • Glycine / analysis*
  • Hemoglobins, Abnormal / analysis*
  • Humans
  • Infant, Newborn
  • Malaysia
  • Peptides / blood

Substances

  • Hemoglobins, Abnormal
  • Peptides
  • Fetal Hemoglobin
  • Cysteine
  • Glycine