Antagonism by folic acid of presynaptic inhibition in the rat cuneate nucleus

Br J Pharmacol. 1974 Mar;50(3):425-7. doi: 10.1111/j.1476-5381.1974.tb09619.x.


Folic acid applied topically in solution to the rat cuneate nucleus reduced presynaptic inhibition produced by peripheral stimulation. This resembles the action of picrotoxin in the same animals and it is possible that these two convulsants are acting in a similar manner by blockade of the receptors for the presynaptic inhibitory transmitter.

MeSH terms

  • Animals
  • Electric Stimulation
  • Electrodes
  • Evoked Potentials / drug effects
  • Folic Acid / administration & dosage
  • Folic Acid / pharmacology*
  • Medulla Oblongata / drug effects*
  • Neural Inhibition / drug effects
  • Picrotoxin / pharmacology
  • Rats
  • Synapses / drug effects*
  • Time Factors


  • Picrotoxin
  • Folic Acid