Treatment of diabetic coma with continuous low-dose infusion of insulin

Br Med J. 1974 Jun 29;2(5921):687-90. doi: 10.1136/bmj.2.5921.687.

Abstract

Thirty-eight patients in diabetic coma from four different centres were treated with a continuous low-dose intravenous infusion of insulin at an average dose of 7.2 IU/hr. All patients recovered rapidly except for one profoundly shocked patient who died. The mean fall in plasma glucose was 58% four hours after the start of insulin. Blood ketone bodies and plasma free fatty acids showed a similar response. There was no significant difference in plasma glucose response according to severity of acidosis or previous treatment with insulin. Hypokalaemia was uncommon. In the treatment of diabetic coma this technique has proved simple, safe, and effective.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Glucose / analysis
  • Child
  • Diabetic Coma / drug therapy*
  • Diabetic Coma / physiopathology
  • Fatty Acids / blood
  • Female
  • Glycerol / blood
  • Humans
  • Infusions, Parenteral
  • Insulin / administration & dosage*
  • Insulin / blood
  • Insulin / pharmacology
  • Insulin / therapeutic use
  • Ketone Bodies / blood
  • Lactates / blood
  • Male
  • Middle Aged
  • Potassium / blood

Substances

  • Blood Glucose
  • Fatty Acids
  • Insulin
  • Ketone Bodies
  • Lactates
  • Glycerol
  • Potassium