Hydroxyzine hydrochloride: possible adverse cardiac interactions

Psychopharmacol Commun. 1975;1(1):61-5.


Hydroxyzine hydrochloride may produce abnormal ventricular repolarization when given in substratial doses or to susceptible individuals. Phenothiazines, such as thioridazine, tricyclic antidepressants, or antiparkinson drugs, any of which may be given concurrently to psychiatric patients, may augment this effect as well as atropine, quinidine or procainamide. Such EKG abnormalities may increase the likelihood of dysrhythmias and sudden death.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Antidepressive Agents, Tricyclic / adverse effects
  • Antiparkinson Agents / adverse effects
  • Antipsychotic Agents / adverse effects
  • Clinical Trials as Topic
  • Drug Interactions
  • Electrocardiography
  • Heart Diseases / chemically induced*
  • Humans
  • Hydroxyzine / adverse effects*
  • Lithium / adverse effects
  • Male
  • Phenothiazines


  • Antidepressive Agents, Tricyclic
  • Antiparkinson Agents
  • Antipsychotic Agents
  • Phenothiazines
  • Hydroxyzine
  • Lithium