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. 1974 Mar 22;68(2):335-43.
doi: 10.1016/0006-8993(74)90402-8.

Cataplectic-like behavior in cats after micro-injections of carbachol in pontine reticular formation

M M Mitler, W C Dement

Cataplectic-like behavior in cats after micro-injections of carbachol in pontine reticular formation

M M Mitler et al. Brain Res. .
No abstract available

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Figures

Fig. 1
Fig. 1
These tracings represent the effects of bilateral micro-injections of carbachol in the pontine reticular formation of chronically implanted cats. a: baseline; b: early response to injection; c: representative episode of atonia 7 h post-injection; d: representative episode of atonia 15 h post-injection. Note the eye movement and PGO activity during atonic periods.
Fig. 2
Fig. 2
These tracings summarize effects observed when bilateral micro-injections of carbachol were given in a C2 sectioned, encéphale isolé preparation, a: baseline, note the tonic EMG activity and presence of the digastric reflex, b: representative episode of atonia; note diminution of EMG activity and low amplitude of digastric reflex. Nystagmoid eye movements and attendant LGN and cortical potentials are also present, c: failure of atropine to block motor inhibition; note abrupt EMG diminution and associated cortical desynchronization.
Fig. 2
Fig. 2
These tracings summarize effects observed when bilateral micro-injections of carbachol were given in a C2 sectioned, encéphale isolé preparation, a: baseline, note the tonic EMG activity and presence of the digastric reflex, b: representative episode of atonia; note diminution of EMG activity and low amplitude of digastric reflex. Nystagmoid eye movements and attendant LGN and cortical potentials are also present, c: failure of atropine to block motor inhibition; note abrupt EMG diminution and associated cortical desynchronization.
Fig. 3
Fig. 3
This figure presents histological verification of cannula placement, a: representative coronal section through the ports at the level of the inferior colliculus. Note the bilateral lesions just below and lateral to the central grey. In the serial slides immediately caudal to this one, the lesion on the right side disappears and the lesion on the left side moves ventrally approximately 1 mm. This apparent lack of symmetry may be due to making sections slightly off the coronal plane, to slight anatomical asymmetry, or to slight errors in stereotaxic placement, b: summary of placements drawn on a stylized coronal section at the P 1.5 level. The 4 pairs of numbers enclosed by circles denote sites in which bilateral carbachol micro-injections precipitated motor inhibition; the 3 pairs of numbers enclosed by squares denote negative sites; ‘A’ prefixes refer to acute cats and ‘C’ prefixes refer to chronic cats.
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References

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