Epileptic-type convulsions and magnesium deficiency

Aviat Space Environ Med. 1979 Jul;50(7):734-5.


Immediately following 4 h of continuous exercise at +/- 45% Vo2max in heat, a 23-year-old, well-trained man displayed epileptic-type convulsions. One week preceeding this incident, he completed an identical work test successfully under room temperature conditions. An assessment of his physiological and biochemical results indicated only one abnormality: during exercise in heat, an abnormally low serum magnesium concentration prevailed for most of the test. Treatment with phenobarb and magnesium chloride enteric tablets ("Slow Mag", 2 x 535 mg/d) reversed the biochemical abnormality. After checking his resting serum magnesium, the subject subsequently heat acclimatized and repeated similar treadmill tests as before without any ill effects.

Publication types

  • Case Reports

MeSH terms

  • Acclimatization
  • Adult
  • Chlorides / therapeutic use
  • Epilepsy / etiology
  • Hot Temperature / adverse effects
  • Humans
  • Magnesium / therapeutic use
  • Magnesium Deficiency / complications*
  • Magnesium Deficiency / drug therapy
  • Magnesium Deficiency / etiology
  • Male
  • Phenobarbital / therapeutic use
  • Physical Exertion
  • Seizures / drug therapy
  • Seizures / etiology*


  • Chlorides
  • Magnesium
  • Phenobarbital