A sebotrophic stimulus in benign and malignant breast disease

Lancet. 1975 Feb 22;1(7904):428-9. doi: 10.1016/s0140-6736(75)91493-2.


The sebum-excretion rate (S.E.R.) has been found to be increased in patients with benign as well as malignant breast disease. The S.E.R. was not increased in patients undergoing surgery for other diseases. It is considered that the sebotrophic hormone may also be mammotrophic. Drugs such as reserpine and the phenothiazines which increase sebum production may perhaps provoke benign as well as malignant breast disease.

MeSH terms

  • Acne Vulgaris / complications
  • Adult
  • Age Factors
  • Aged
  • Breast Diseases / complications
  • Breast Diseases / physiopathology*
  • Breast Neoplasms / complications
  • Breast Neoplasms / physiopathology*
  • Dermatitis, Seborrheic / complications
  • Dermatitis, Seborrheic / etiology
  • Female
  • Humans
  • Melanocyte-Stimulating Hormones / physiology
  • Middle Aged
  • Sebaceous Glands / physiopathology
  • Sebum / metabolism*
  • Secretory Rate
  • Time Factors


  • Melanocyte-Stimulating Hormones