Diaspirins that cross-link beta chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate

Biochemistry. 1979 Oct 2;18(20):4265-70. doi: 10.1021/bi00587a001.

Abstract

Two double-headed aspirins, bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate, have been found to be potent acylating agents of intracellular hemoglobin (A or S) in vitro. Furthermore, each of these reagents cross-links beta chains of hemoglobin, probably at the beta cleft. The modified hemoglobins show increased oxygen affinities and reduced gelation or sickling tendencies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acylation
  • Aspirin / analogs & derivatives*
  • Cross-Linking Reagents*
  • Erythrocytes / metabolism
  • Fumarates
  • Hemoglobin A
  • Hemoglobin, Sickle
  • Hemoglobins*
  • Humans
  • Macromolecular Substances
  • Oxygen / blood
  • Oxyhemoglobins
  • Succinates

Substances

  • Cross-Linking Reagents
  • Fumarates
  • Hemoglobin, Sickle
  • Hemoglobins
  • Macromolecular Substances
  • Oxyhemoglobins
  • Succinates
  • Hemoglobin A
  • Aspirin
  • Oxygen