Abstract
Two double-headed aspirins, bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate, have been found to be potent acylating agents of intracellular hemoglobin (A or S) in vitro. Furthermore, each of these reagents cross-links beta chains of hemoglobin, probably at the beta cleft. The modified hemoglobins show increased oxygen affinities and reduced gelation or sickling tendencies.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acylation
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Aspirin / analogs & derivatives*
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Cross-Linking Reagents*
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Erythrocytes / metabolism
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Fumarates
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Hemoglobin A
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Hemoglobin, Sickle
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Hemoglobins*
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Humans
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Macromolecular Substances
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Oxygen / blood
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Oxyhemoglobins
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Succinates
Substances
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Cross-Linking Reagents
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Fumarates
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Hemoglobin, Sickle
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Hemoglobins
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Macromolecular Substances
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Oxyhemoglobins
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Succinates
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Hemoglobin A
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Aspirin
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Oxygen