Escherichia coli: high resistance or dependence on streptomycin produced by the same allele

Science. 1968 Aug 2;161(3840):478-9. doi: 10.1126/science.161.3840.478.

Abstract

Mutations to streptomycin resistance in Escherichia coli K12, when transferred to a C strain, can confer dependence on streptomycin. These alternatives in expression of the allele are probably a result of interaction between two ribosomal proteins.

MeSH terms

  • Alleles*
  • Bacterial Proteins / metabolism
  • Drug Resistance, Microbial*
  • Escherichia coli / metabolism*
  • Genetics, Microbial
  • Mutation*
  • Pharmacogenetics
  • Recombination, Genetic
  • Ribosomes / metabolism
  • Streptomycin / pharmacology*
  • Transduction, Genetic

Substances

  • Bacterial Proteins
  • Streptomycin