Randomised clinical trial of strategies for improving medication compliance in primary hypertension

Lancet. 1975 May 31;1(7918):1205-7. doi: 10.1016/s0140-6736(75)92192-3.


230 Canadian steelworkers with hypertension took part in a randomised trial to see if compliance with antihypertensive drug regimens could be improved. For care and follow-up these men were randomly allocated to see either their own family doctors outside working-hours or industrial physicians during work shifts; the same men were randomly allocated to receive or not receive an educational programme aimed at instructing them about hypertension and its treatment. Surprisingly, the convenience of follow-up at work had no effect upon these men's compliance with antihypertensive drug regimens. Similarly, although men receiving health education learned a lot about hypertension, they were not more likely to take their medicine.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Attitude to Health
  • Clinical Trials as Topic
  • Community Participation
  • Follow-Up Studies
  • Health Education
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Metallurgy
  • Occupational Medicine
  • Ontario
  • Patient Compliance*
  • Patient Dropouts


  • Antihypertensive Agents