Use of co-trimoxazole in chronic renal failure

Lancet. 1975 May 31;1(7918):1216-8. doi: 10.1016/s0140-6736(75)92196-0.

Abstract

Twenty patients with chronic renal failure and either urinary or respiratory tract infection were treated with co-trimoxazole. Seventeen patients showed no deterioration in renal function while receiving co-trimoxazole. Deterioration in renal function during treatment in the other three patients was due to factors other than administration of the drug. It is concluded that co-trimoxazole can be used in patients with chronic renal failure provided the dose is adjusted according to the degree of renal failure.

MeSH terms

  • Adult
  • Aged
  • Creatinine / blood
  • Drug Combinations
  • Female
  • Humans
  • Kidney / physiopathology
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / drug therapy*
  • Kidney Failure, Chronic / physiopathology
  • Kidney Function Tests
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Prospective Studies
  • Sulfamethoxazole / administration & dosage
  • Sulfamethoxazole / therapeutic use*
  • Tablets
  • Trimethoprim / administration & dosage
  • Trimethoprim / therapeutic use*
  • Urea / blood

Substances

  • Drug Combinations
  • Tablets
  • Urea
  • Trimethoprim
  • Creatinine
  • Sulfamethoxazole